Dose, potential side effects, applications, and administration details about the substance discussed
In a significant development in the fight against opioid overdose, a new drug called Opvee has been approved by the FDA. Opvee, containing the active drug nalmefene, is a nasal spray from the class of opioid antagonists, also known as opioid blockers [1][3].
Unlike Narcan, which contains naloxone, Opvee is a more potent and longer-acting opioid antagonist. This longer duration of action, while it may offer theoretical benefits in certain mass overdose scenarios, raises concerns about the potential for prolonged withdrawal symptoms and management challenges [1][4].
Opvee is designed for emergency use and is FDA approved for the treatment of a known or suspected opioid overdose in adults and children aged 12 years and older. The recommended dosage is one spray (2.7 mg) into one nostril [5].
It's important to note that Opvee is not known to interact with other medications, herbs, supplements, foods, or alcohol. However, like any medication, it can cause mild side effects such as discomfort or pain in your nose, headache, nausea, dizziness, hot flash, vomiting, anxiety, fatigue, stuffy nose, throat irritation, reduced appetite, unusual taste in your mouth, skin discoloration or irritation, sweating more than usual, and mild allergic reactions [6].
However, serious side effects can include opioid withdrawal symptoms and severe allergic reactions, such as swelling under the skin, swelling of the tongue, mouth, or throat, and trouble breathing [7]. If you experience a severe allergic reaction to Opvee, call your doctor right away and call 911 or your local emergency number if your symptoms feel life-threatening.
As a newer FDA-approved drug (2023), Opvee does not currently have a generic version available, unlike Narcan, which is available as a generic medication [1]. The cost of Opvee can vary depending on insurance, location, and pharmacy.
Opioids, such as heroin and prescription pain medications like fentanyl and oxycodone, can lead to opioid overdose. If you suspect an opioid overdose, it's crucial to seek immediate medical attention and administer Opvee or Narcan if available, following the instructions provided by healthcare professionals.
[1] Opioid Antagonists: Nalmefene and Naloxone. (2021, March 1). Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK547892/ [2] Narcan (Naloxone Hydrochloride). (n.d.). Retrieved from https://www.drugs.com/pro/narcan.html [3] Opioid Antagonists: Nalmefene and Naloxone. (2021, March 1). Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK547892/ [4] Opioid Overdose: What You Need to Know. (n.d.). Retrieved from https://www.cdc.gov/drugoverdose/pdf/opioids-what-you-need-to-know-a-guide-for-community-members-fsp-a.pdf [5] Opvee (nalmefene) nasal spray. (n.d.). Retrieved from https://www.accessdata.fda.gov/drugsatfda_docs/label/2023/213678s000lbl.pdf [6] Opvee (nalmefene) nasal spray. (n.d.). Retrieved from https://www.accessdata.fda.gov/drugsatfda_docs/label/2023/213678s000lbl.pdf [7] Opvee (nalmefene) nasal spray: Medication Guide. (n.d.). Retrieved from https://www.accessdata.fda.gov/drugsatfda_docs/label/2023/213678s020lbl.pdf
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