Genetic Differences May Explain Higher Depression Risk in Women
A groundbreaking study has identified genetic differences that may explain why women are twice as likely to experience depression than men. The findings could pave the way for targeted treatments, while environmental factors also play a significant role. Meanwhile, the Nobel Prize in Physiology or Medicine was awarded for a different medical breakthrough.
The study, conducted by QIMR Berghofer Medical Research Institute, found 16 genetic variants associated with depression in women and 8 in men. This suggests that genetic differences may be a key component in the higher prevalence of depression in women. The genetic likelihood of developing depression is significantly higher in women than in men.
In addition to genetic factors, environmental influences such as sexual and interpersonal violence also contribute to depression. Men are less likely to seek help, leading to underdiagnosis. The study's findings could lead to targeted pharmaceutical treatments for both sexes by further investigating the specific mechanisms of depression in each.
The study's findings highlight the importance of considering sex-specific factors in depression research and treatment. Meanwhile, the Nobel Prize in Physiology or Medicine was awarded in 2018 to James Allison and Tasuku Honjo for their work on cancer therapy by inhibition of negative immune regulation.
