Zykadia Dosage Guidelines: Forms, Potencies, Administration Methods, and Additional Information
Zykadia, a brand-name drug, is used to treat a specific type of non-small cell lung cancer with ALK gene mutations that has spread to other parts of the body. This kinase inhibitor, available only under the brand name, is meant to be taken as a long-term treatment.
The typical recommended dosage for people with non-small cell lung cancer is 450 mg once per day, and it should be taken with a meal or snack. Zykadia is an oral tablet that comes in one strength of 150 milligrams (mg).
However, it's essential to note that Zykadia can cause side effects such as nausea, vomiting, diarrhea, stomach pain, elevated liver blood tests, QT prolongation, high blood sugar, slow heart rate, pancreatitis, interstitial lung disease, and should be used cautiously in these cases.
Dosage Adjustments
Dosage adjustments for Zykadia in liver and renal impairment have been outlined. For mild to moderate hepatic impairment (Child-Pugh A or B), no dosage adjustment is recommended. In severe hepatic impairment (Child-Pugh C), the dose should be reduced by approximately one-third, rounded to the nearest multiple of the 150 mg tablet strength. For mild to moderate renal impairment, no adjustments are required, but data are insufficient for severe renal impairment.
In cases of adverse reactions or toxicities, dose interruption or reduction may be necessary based on clinical judgment. Common adverse reactions with ceritinib include gastrointestinal symptoms and hepatotoxicity.
While specific dose adjustments for interactions are not detailed, close clinical monitoring and individualized adjustments remain the standard approach. Pharmacies may offer labels with large print, braille, or a code you scan with a smartphone to convert text to speech to aid in medication management.
If trouble opening medication bottles, ask your pharmacist about putting Zykadia in an easy-open container. If you vomit shortly after taking Zykadia, do not take an additional dose. Wait until your next scheduled dose time to take the medication again.
It's crucial to consult your doctor or another healthcare professional before taking any medication, and never change your dosage of Zykadia without their recommendation. A medication reminder can help ensure you don't miss a dose.
These recommendations are consistent with the drug’s prescribing information and clinical guidelines for cancer therapies. For more detailed information, consult the drug’s product information or speak with your healthcare provider.
References: - Dosage adjustments for ceritinib in liver impairment and renal impairment from Drugs.com[1]. - [Other relevant references if available]
[1] Retrieved from https://www.drugs.com/dosage/zykadia.html
